Multiple Sclerosis, Menstrual Cycle and Physical Acivity

Exclusion Criteria

• •a score \< 2 or \> 6 on the Expanded Disability Status Scale (EDSS);
• •experienced a relapse in the 12 months prior to enrolment;
• •received corticosteroid treatment in the previous 2 months;
• •participated in a structured exercise programme in the past 6 months;
• •secondary amenorrhoea (absence of ≥ 3 consecutive periods despite not being pregnant and having previous menstruation);
• •used or currently use hormonal contraceptives for 3 months before recruitment
• •reported musculoskeletal or neurological injuries not associated with MS, recent surgical interventions, or pregnancies in the previous year,
• •have unrelated diseases to MS