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Oxygen Extraction-guided Transfusion | Clinical Trials | Clareo Health

RECRUITINGNA

Oxygen Extraction-guided Transfusion

Oxygen Extraction-guided Transfusion Strategy in Critically Ill Patients. A Randomized Controlled Trial.

NCT06102590•Università degli Studi di Ferrara

Summary

In critically ill patients, optimized strategies for red blood cells transfusion (RBCT) are still controversial. Most recent guidelines suggest that clinical practice in ICU setting should follow a restrictive approach to RBCT (i.e., hemoglonim level \< 7.0 g/dL).In our previous study, oxygen extraction ratio (O2ER) has shown good performance as a marker to identify the correct timing for RBCT, potentially affecting 90-day mortality in non-bleeding, critically ill patients \[11\]. Moreover, our data suggested that an individualized strategy for RBCT may reduce the incidence of acute kidney injury (AKI), which is possibly related to a better delivery of oxygen and organ perfusion.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Hb levels ≤ 9.0 g/dL (as confirmed through a blood test and/or through blood gas analysis)
•Presence of an arterial line and a central venous line (either jugular or subclavian), with confirmed correct position of the catheter tip at the atrio-caval junction (allowing correct estimation of central venous saturation, ScvO2).

Exclusion Criteria

•Age \< 18 years;
•Pregnancy
•Clinical evidence of acute bleeding
•Diagnosis of haematological malignancy
•Diagnosis of sickle cell disease, or other diseases exposing the patient to chronic RCBTs
•Acquired or congenital disorders of coagulation
•Patients with ongoing AKI of stage 1 or worse and/or known chronic kidney disease (CKD) of stage G3a or worse, defined as glomerular filtration rate below 60 for a minimum of 3 months

Locations (4)

Hospital Erasme

Brussels, Belgium

Università di Ferrara

Ferrara, Ferrara, Italy

Università di Perugia

Perugia, Italy, Italy

Anestesia e Rianimazione Cardio-Toraco-Vascolare

Siena, Italy

Key Dates

Start Date

November 4, 2023

Primary Completion Date

November 1, 2026

Completion Date

January 1, 2027

Last Updated

July 31, 2025

Enrollment

324

ESTIMATED participants

Conditions

Blood Transfusion

Interventions

Individualized red blood cell transfusion strategy

OTHER

European guidelines red blood cell transfusion strategy

OTHER

Hemoglobin Levels for Blood Transfusions During and After Surgery

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Blood TransfusionSurgery

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RECRUITINGNA

Biological Parameters Changes After Autologous Blood Transfusion of Red Blood Cells (200 Ml) in Healthy Volunteers.

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The Focus is on the Detection of the Consequences of Autologous Blood Transfusion in Healthy Volunteers

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: July 31, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Oxygen Extraction-guided Transfusion

Inclusion Criteria

Exclusion Criteria

Hemoglobin Levels for Blood Transfusions During and After Surgery

Biological Parameters Changes After Autologous Blood Transfusion of Red Blood Cells (200 Ml) in Healthy Volunteers.

Respiratory Trends During Blood Transfusions in Newborns.

The Safety and Efficacy of Autologous Transfusion in Spinal Surgery for Lung Cancer With Spinal Metastasis

Use of the Hemanext One® Hypoxic Red Blood Cell Storage System for Transfusion in Thalassemia Patients

Ostene in Thoracolumbar Decompression and Fusion Evaluated With VIBE