Study to Assess the Safety and Efficacy of ZX-7101A in Adolescents With Influenza

Exclusion Criteria

• •1. Patients with severe influenza virus infection requiring inpatient treatment.(Meet any one of the following criteria) （1）Severe cases with one of the following conditions： Persistent high fever for more than 3 days, accompanied by severe cough, purulent sputum, bloody sputum, or chest pain; Fast breathing rate, difficulty breathing, cyanosis of lips; Delayed response, drowsiness, restlessness, and other mental changes or seizures; Severe vomiting, diarrhea, and dehydration symptoms; Concomitant pneumonia; Significant exacerbation of existing underlying diseases; Other clinical situations that require hospitalization. （2）Critical cases with one of the following conditions(Including but not limited to)： Respiratory failure; Acute necrotizing encephalopathy; Shock; Multiple organ dysfunction; Other serious clinical situations that require monitoring and treatment.
• •2. High risk population for severe cases. (Meet any one of the following criteria):
• •（1）Accompanied by the following basic diseases and judged by the investigators to be clinically significant, such as lung diseases, liver diseases, kidney diseases, hematological system diseases, heart diseases, neurological and neuromuscular diseases that affect the ability to clear respiratory secretions, metabolic and endocrine system diseases, etc; （2）Subjects with low immune function, such as malignant tumors, organ or bone marrow transplants, HIV infections, or those who have been taking immunosuppressants for the past 3 months; （3）Clinical significance of correcting QT interval abnormalities in electrocardiogram display; (QTc\>440ms in male or QTc\>450ms in female); （4）Subjects who require long-term use of drugs containing aspirin or salicylates : It is necessary to take medication containing aspirin or salicylate regularly every day for more than 14 days; （5）BMI exceeds the standards. 3.Bronchitis, pneumonia, pleural effusion or interstitial disease confirmed by chest imaging \[X-ray (anteroposterior or anteroposterior)/CT\] and judged clinically significant by the investigator at screening.
• •4.Subjects who have developed acute respiratory tract infection, otitis media, and sinusitis within 2 weeks before screening.
• •5.Subjects with other infections requiring systemic anti-infective treatment, or blood routine examination at screening: \<13 years of age ：white blood cell count (WBC) \> 11.3 × 109/L(venous blood);≥13 to\<18 years of age ：white blood cell count (WBC) \> 11.0 × 109/L(venous blood).
• •6.Subjects with purulent sputum or suppurative tonsillitis. 7.Have difficulty in swallowing drugs or have a history of gastrointestinal diseases that seriously affect drug absorption.
• •8.Suspected allergic to active ingredients or excipients of the investigational product.
• •9.Body weight \< 20 kg. 10.Medications against influenza virus within 7 days before screening. 11.Have received live vaccines or attenuated live vaccines within 14 days before randomization, influenza vaccines within 6 months before randomization.
• •12.Suspected or confirmed a history of alcohol or drug abuse.