Surveillance for Multifocal GGNs

Inclusion Criteria

• •1. Demonstrates the following on thin-section computed tomography (TSCT) scan:
• •1. Presence of three or more GGNs (bilateral lesions are permitted).
• •2. All lesions have remained stable without regression or enlargement for at least 3 months.
• •3. The dominant lesion (the lesion with the largest maximum tumor diameter) has a maximum tumor diameter \>=0.6cm and \<=2cm.
• •4. CTR \<=0.25 in all lesions.
• •5. No lymph node with a diameter \>1cm in the mediastinal view.
• •6. Not adjacent to the pleura in dominant lesion and no sign of pleural retraction in any lesions.
• •2. Aged 18-75 years.
• •3. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
• •4. Has not previously undergo any anti-tumor drug or radiation therapy.
• •5. Written informed consent.