Induction Toripalimab and Chemotherapy in Locally Advanced Cervical Cancer

Exclusion Criteria

• •1. Concomitant other malignancies;
• •2. Patients with metastatic or recurrent disease;
• •3. Patients received any form of treatment before enrollment;
• •4. Severe concomitant chronic diseases (diabetes, hypertension, etc.) or acute infections;
• •5. Impaired hematological, renal or hepatic functions:
• •1. Hemoglobin \< 9.0 g/dl
• •2. Neutrophils \< 2000 cells/μl; Leukocytes \< 4 × 109/L
• •3. Platelets \> 100 × 109/L
• •4. Serum ALT/AST \> 2.5×UNL
• •5. Serum Total bilirubin \> 1.5× UNL
• •g. Serum urea nitrogen (BUN) \> 1.5 × upper normal limit (UNL) h. Serum creatinine (Cr) \> 1.5 × upper normal limit (UNL)
• •6. Patients with obvious arrhythmia, myocardial ischemia, severe atrioventricular block, cardiac insufficiency or severe heart valve disease;
• •7. Patients with uncontrolled mental diseases;
• •8. Pregnant or lactating woman;
• •9. Participating in other clinical trials;
• •10. Anyone considered not suitable for enrollment by principal investigator;