Presynaptic Imaging in Major Depressive Episodes After COVID-19

Exclusion Criteria

• •Age 18 to 75.
• •Good general physical health with no active medical conditions based on self-report (except migraine or PASC).
• •Use of antidepressants in the previous month (6 weeks for fluoxetine).
• •Use of stimulant medication affecting dopamine release in the previous month
• •Use of antipsychotics in the previous month
• •History of neurological disease (except migraine, and PASC) based on self-report
• •Use of medications or herbal products or natural health products with central nervous system effects in past 2 weeks based on self-report
• •Presence of cigarette smoking in the past two months, based on self-report
• •Lifetime diagnosis of severe Substance or Alcohol Use Disorder, or diagnosis of mild to moderate Substance or Alcohol Use Disorder in the past two years, based on self-report and verified by the Research Version of Structured Clinical Interview for Diagnostic and Statistical Manual-5 (SCID-5-RV)
• •Use of recreational drugs, including marijuana, in the past two months, based on self-report and verified by the Research Version of Structured Clinical Interview for Diagnostic and Statistical Manual-5 (SCID-5-RV)
• •Positive urine drug or cotinine screen at any timepoint during the study
• •History of psychotic symptoms secondary to schizophrenia, schizophreniform, bipolar disorder, or brief psychotic disorder prior to COVID-19, based on self-report and verified by the Research Version of Structured Clinical Interview for Diagnostic and Statistical Manual-5 (SCID-5-RV)
• •Currently pregnant, based on self-report or positive pregnancy test at any timepoint during the study, in females (in our PET Centre females up to 65 years of age are given a urine pregnancy test prior to every PET scan)
• •Breastfeeding (for females)
• •Current disorders of coagulation, blood or ongoing use of anticoagulant medication, based on self-report
• •Claustrophobia, based on self-report
• •Weight over 400lbs and height over 7ft (requirements for fitting in the scanners and hospital gowns)
• •Presence of metal implant, object or electrical devices that are contraindicated for MRI, based on self-report
• •Severe allergic reaction to alcohol