PRIMARY OBJECTIVE:
I. To determine if altered measurement results of ICG after pancreatectomy is associated with leak rates.
OUTLINE: This is an observational study.
Patients receive indocyanine green intravenously (IV) during surgery, undergo imaging and have their medical records reviewed on study.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Participant scheduled for open pancreaticoduodenectomy or distal pancreatectomy for any diagnosis
Participant ≥ 18 years of age
Ability to understand nature and individual consequences of clinical trial
Written informed consent from participant or legally authorized representative
For participants of childbearing potential, a negative pregnancy test and adequate contraception until 14 days after trial intervention
Participant needs to have an operative drain (any closed suction drain) after the procedure
Participants that do not require arterial reconstruction
Participants that require minor portal venous recounstructions including patch venoplasty
You may not be if
Patients with previous history of adverse reaction to contrast dye, ICG or components of the dye
Prior pancreatectomy
Known diagnosis of hepatic insufficiency, hepatitis, liver fibrosis or cirrhosis, or chronic pancreatitis
Because this study focuses on hypoperfusion, patients will be excluded if in postoperative day 3-5 had any of the following: persistent SBP \<90 mmHg unresponsive to 1L crystalloid, unexpected ICU transfer, blood transfusion of \>2 units intraoperatively or 1 postoperatively, vasopressor treatment or ACLS protocol initiation
Organ failure, anuria or NSQIP-identified complication will be reviewed by PI and attending surgeon and excluded
Patients that require arterial reconstruction as part of their procedures
