CD19CD22 CAR-T Therapy in Patients With High-Risk B Acute Lymphoblastic Leukemia (B-ALL).

Exclusion Criteria

• •1. History of craniocerebral trauma, conscious disturbance, epilepsy, cerebrovascular ischemia, and cerebrovascular hemorrhagic diseases;
• •2. Electrocardiogram shows prolonged QT interval, severe heart diseases such as severe arrhythmia in the past;
• •3. Pregnant (or lactating) women;
• •4. Patients with severe active infections (excluding simple urinary tract infection and bacterial pharyngitis);
• •5. Human immunodeficiency virus (HIV) positive; Active infection of hepatitis B virus or hepatitis C virus
• •6. Previously treated with any CAR-T cell product or other genetically-modified T cell therapies;
• •7. Creatinine\>2.5mg/dl, or ALT / AST \> 3 times of normal amounts, or bilirubin\>2.0 mg/dl;
• •8. Other uncontrolled diseases that were not suitable for this trial;
• •9. Any situations that the investigator believes may increase the risk of patients or interfere with the results of study.