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Observational Analysis of the Association of Drug Activity Measured in Viable Tumour Tissues ex Vivo and Clinical Response in Ovarian Cancer: A Basic Research Study
EXCYTE-1 is a multicentre, prospective observational study to investigate the relationship between ex vivo drug response (EVDR), measured in ovarian tumour-derived samples using high content imaging, and actual patient clinical response. Patients with newly diagnosed or relapsed/refractory epithelial ovarian carcinoma, that present with malignant effusions (ascites or pleural effusions), will be enrolled in the study before starting their initial or next treatment line. Enrolled patients will be asked to provide ascites, peripheral blood and fresh tumour tissue if available. Samples will be shipped to the sponsor laboratory and their response to standard of care drugs evaluated ex vivo. Participants will: * provide samples during routine clinical procedures * agree that data about their medical history, diagnosis and health status at the following timepoints are collected: at signature of the consent form, at the time samples are provided, at start of the therapy, upon completion of the therapy, regularly after completion of the therapy
Age
18 - 125 years
Sex
FEMALE
Healthy Volunteers
No
Barmherzige Schwestern Linz, Abteilung Gynäkologie und Geburtshilfe
Linz, Upper Austria, Austria
Med. Universität Wien - Universitätsklinik für Frauenheilkunde
Vienna, Austria
Evang. Kliniken Essen-Mitte gGmbH
Essen, North Rhine-Westphalia, Germany
Department für Frauengesundheit/Universitäts-Frauenklinik Tübingen
Tübingen, Germany
Start Date
April 14, 2023
Primary Completion Date
August 14, 2024
Completion Date
August 14, 2024
Last Updated
September 26, 2024
13
ACTUAL participants
Biological sample collection
OTHER
Lead Sponsor
Exscientia AI Limited
Collaborators
NCT07432633
NCT05867251
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
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