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The objective of this prospective observational single center study is to investigate donor-derived cell-free DNA (ddcfDNA), peripheral blood platelet mRNA, peripheral blood extracellular vesicle mRNA, and peripheral blood leukocyte mRNA expression in recognition of clinically significant endomyocardial biopsy (EMB) proven acute rejection in human heart transplant recipients. In detail, the objective is to develop novel biomarkers and liquid biopsies for diagnosis, prognosis, and targeted molecular therapy for primary graft failure, ischemia-reperfusion injury, acute rejection, and development of late graft failure and cardiac allograft vasculopathy, and for monitoring immunosuppression after heart transplantation.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
Yes
Helsinki University Hospital
Helsinki, Uusimaa, Finland
Start Date
January 22, 2019
Primary Completion Date
December 31, 2025
Completion Date
December 31, 2025
Last Updated
October 3, 2023
100
ESTIMATED participants
Cell-free DNA
DIAGNOSTIC_TEST
Lead Sponsor
Helsinki University Central Hospital
NCT05732779
NCT05184426
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