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A Study of Neurodegeneration and Neuronal Fluctuations in Lewy Body Disease and Alzheimer's Disease | Clinical Trials | Clareo Health

RECRUITING

A Study of Neurodegeneration and Neuronal Fluctuations in Lewy Body Disease and Alzheimer's Disease

Neurodegeneration and Neuronal Fluctuations in Lewy Body Disease and Alzheimer Disease

NCT06057909•Mayo Clinic

View on ClinicalTrials.gov

Summary

The purpose of this research study is to investigate how the brain, memory, thinking, and motor behavior change both in individuals with movement and/or cognitive disorders, as well as healthy individuals. Researchers will look at measurements of memory, thinking, brain wave and muscle activity, daily functioning, and brain scans to learn more about brain disorders such as Alzheimer disease and Lewy body disease.

Eligibility

Age

50 - 95 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Use English as their primary language.
•Be willing to undergo health and cognitive assessments, as well as brain MRI and EEG study.
•Will be encouraged to have an available study partner (also called a "co-participant") who is familiar with the participant's daily functioning.
•This study will be limited to healthy individuals, and patients who have a clinical diagnosis made by a board-certified neurologist of Lewy body disease or Alzheimer disease.
•All individuals must be capable of providing informed consent and complying with the trial procedures. Realizing the challenge of obtaining informed consent from cognitively impaired individuals, time is specifically scheduled to foster an informative, supportive interview with the participant and caregiver/legal guardian (typically a spouse or child according to Arizona law and IRB guidelines).

Exclusion Criteria

•All participants will receive copies of the signed ICFs (including signatures of those obtaining consent).
•All participants have the right to withdraw from the study at any time.
•Individuals will be excluded if they have significant sensory (visual and hearing) deficits or major medical or psychiatric illnesses which would limit participation.
•Participants will also be excluded if they have history of other major neurologic disorders including stroke, epilepsy, meningitis/encephalitis, metabolic or toxic encephalopathy, penetrating or severe closed head injury, brain tumor/other structural lesion, other primary movement disorders (such as essential tremor, dystonia, chorea, multiple system atrophy, progressive supranuclear palsy, corticobasal syndrome).
•If the subject is a woman of childbearing potential, due to unknown risks to the fetus, they must have a pregnancy test. Individuals who have a history metalworking involving cutting processes such as grinding, filing, shaving, and threading, or history of eye injury involving metal, will also be excluded unless they have had prior documented radiological clearance for MRI.

Locations (1)

Mayo Clinic Arizona

Scottsdale, Arizona, United States

Key Dates

Start Date

April 5, 2024

Primary Completion Date

June 1, 2027

Completion Date

June 1, 2027

Last Updated

February 3, 2026

Enrollment

ESTIMATED participants

Conditions

Lewy Body DiseaseAlzheimer DiseaseHealthy

Interventions

Magnetic Resonance Imaging

DIAGNOSTIC_TEST

Electroencephalography

DIAGNOSTIC_TEST

Electromyography

DIAGNOSTIC_TEST

Contacts

Sara Dresler

CONTACT

480-301-6279 dresler.sara@mayo.edu

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 3, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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A Study of Neurodegeneration and Neuronal Fluctuations in Lewy Body Disease and Alzheimer's Disease

Inclusion Criteria

Exclusion Criteria

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