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COMPLETEDNCT06049537

Studying Respiratory Infections and Colonisation in Children Using Daily Minimally-invasive Nasal Sampling

Rationale: Respiratory tract infections (RTI) are a major cause of morbidity in young children in high- income countries and the major cause of mortality in developing countries. Causative bacteria an...

Lead sponsor: Leiden University Medical Center•1 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Leiden University Medical Center

Collaborators

Spaarne Gasthuis

Age

1 - 5 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Written informed consent obtained from all legal representatives, for example both parents.
•Child aged 1-5 years of age attending day care, peuterspeelzaal or school at least 2 (half) days a week.
•Parents ability and willingness to adhere to protocol-specified procedures, including availability of a freezer at home to store samples. This does not include donation of saliva by parents themselves, which is related to a secondary endpoint.

Exclusion Criteria

•History of respiratory tract infections requiring hospitalization
•Current use of antibiotics, or antibiotics use in past four weeks
•Use of immune-altering medication (such as steroids, including inhaled corticosteroid)
•No history of severe concomitant disease (severe congenital heart disease, bronchopulmonary dysplasia, prematurity \<32 weeks, cystic fibrosis, sickle cell disease, congenital or acquired immunodeficiency disorders, cardiovascular disease, neuromuscular disorders, oncology patients or major congenital anomalies)

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: December 12, 2023Terms

Trial snapshot

StatusCOMPLETED

Phase—

Enrollment46

Start dateJan 2022

Last updatedDec 12, 2023

Condition

Respiratory Tract; Infection, Upper (Acute)Colonization, Asymptomatic

Locations shown

Spaarne Gasthuis

Hoofddorp

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 12, 2023Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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