Lead Sponsor

Janssen Research & Development, LLC

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•Signed informed consent form 18 years of age or older
•Documented diagnosis of ulcerative colitis (UC) of at least 12 weeks prior to screening
•Moderately to severely active UC as per the modified Mayo score
•Demonstrated inadequate response to or intolerance of conventional therapy and/or advanced therapy as defined in the protocol

•Participants with current or prior diagnosis of fulminant colitis and/or toxic megacolon
•UC limited to rectum only or to less than (\<) 15 centimeters (cm) of colon
•Presence of a stoma
•Presence or history of fistula
•History of extensive colonic resection (example, \<30 cm of colon remaining)
•Diagnosis of indeterminate colitis, microscopic colitis, ischemic colitis, Crohn's colitis or clinical findings suggestive of Crohn's disease