Oncotype DX DCIS: Impact on Radiotherapy Decision Making

Exclusion Criteria

• •1. Prior treatment for DCIS or invasive breast cancer in ipsilateral breast.
• •2. Patients with contra-indications to radiotherapy, including prior breast radiotherapy
• •3. Patients who undergo mastectomy for DCIS
• •4. Age \< 45 years old
• •5. Patients with \> 25mm DCIS
• •6. Patients with multifocal DCIS (defined as more than 1 distinct focus of DCIS with at least 50mm of intervening benign tissue)
• •7. Patients with invasive (including microinvasion) disease
• •8. Patients with positive axillary nodal disease (including isolated tumour cells)
• •9. Patients with close (\<1mm) or positive radial margins (unless maximally surgically excised or no further DCIS on re-excision)
• •10. Patients recommended adjuvant endocrine therapy