Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Rhythm Pharmaceuticals, Inc.
Age
12–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Documented evidence of acquired hypothalamic obesity (HO)
Age 12 years and older
Weight gain associated with the hypothalamic injury and a body mass index (BMI) of ≥30 kg/m\^2 for participants ≥18 years of age or BMI ≥95th percentile for age and sex for participants \<18 years of age
Male and female participants agreed to follow study contraception requirements and use a highly effective form of contraception throughout the study and for 90 days after the study
You may not be if
Weight loss \>2% in the previous 3 months for participants ≥18 years of age or \>2% reduction in BMI for participants \<18 years of age
History of major surgical procedure within 30 days
HbA1c \>10.9%
Fasting glucose level \>270 mg/dL
Previous use of MC4R agonists
Diagnosis of Prader-Willi syndrome (PWS) or Rapid-onset obesity with hypoventilation, hypothalamic, autonomic dysregulation, neuroendocrine tumor syndrome (ROHHADNET)
Diagnosis of severe psychiatric disorders; any suicidal ideation, attempt or behavior
History or close family history of skin cancer or melanoma
Clinically significant pulmonary, cardiac, or oncologic disease considered severe enough to interfere with the study and/or confound the results
