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Prediction of Early Recovery of Liver Function After LDLT in Children: An Ambispective Cohort Study | Clinical Trials | Clareo Health

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Prediction of Early Recovery of Liver Function After LDLT in Children: An Ambispective Cohort Study

Prediction of Early Recovery of Liver Function After Living Donor Liver Transplantation in Children: An Ambispective Cohort Study

NCT06045949•Huiwu Xing

View on ClinicalTrials.gov

Summary

The investigators included children with living donor liver transplantation (LDLT) from January 1, 2018 to July 31, 2022 as a retrospective cohort, and the group from August 1, 2022 to June 30, 2023 as a prospective cohort. The investigators collected the demographic and clinicopathological data of donors and recipients, and determined the risk factors of early postoperative delayed recovery of hepatic function (DRHF) by univariate and multivariate Logical regression analyses.

Eligibility

Age

0 - 18 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. children with the indication of LDLT \[cholestatic liver disease (such as BA), metabolic liver disease (such as Wilson's disease and Ornithine transcarbamylase deficiency), acute liver failure (such as drug induced), neoplastic disease (such as hepatoblastoma), vascular disease (such as cavernous transformation of portal vein and congenital absence of portal vein), re-transplantation and others\];
•2. the relatives of the children voluntarily donated part of the liver which met the requirements of LDLT.

Exclusion Criteria

•1. recipients with contraindications of LDLT (such as coagulation dysfunction, acute infection, cardiopulmonary failure);
•2. failure to complete LDLT due to various reasons (such as death during or within 3 days after operation);
•3. recipients or donors with incomplete necessary data.

Locations (1)

Children's Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, China

Key Dates

Start Date

July 31, 2022

Primary Completion Date

September 1, 2023

Completion Date

September 1, 2023

Last Updated

September 21, 2023

Enrollment

230

ACTUAL participants

Conditions

Liver and Biliary Tract Disorders in Duration of PregnancyOther End-stage Liver Diseases in Children