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Different Tidal Volume on Oxygenation, Respiratory Mechanics, and Pulmonary Complications in Older Patients Undergoing Trendelenburg Pneumoperitoneum Surgery | Clinical Trials | Clareo Health

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Different Tidal Volume on Oxygenation, Respiratory Mechanics, and Pulmonary Complications in Older Patients Undergoing Trendelenburg Pneumoperitoneum Surgery

Effect of Intraoperative Low Tidal Volume vs Intermediate Tidal Volume on Oxygenation, Respiratory Mechanics, and Pulmonary Complications in Older Patients Undergoing Trendelenburg Pneumoperitoneum Surgery: A Randomized Clinical Trial

NCT06044402•dong zhang

View on ClinicalTrials.gov

Summary

The investigators want to assess the effect of intraoperative low tidal volume vs intermediate tidal volume on respiratory mechanics, oxygenation and pulmonary complications in older patients undergoing Trendelenburg pneumoperitoneum surgery.

Eligibility

Age

66 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•American Society of Anesthesiologists (ASA) physical status I-III class;
•Colorectal cancer patients;
•Elective laparoscopic colorectal surgery;
•expected duration of surgery greater than 2 hours.

Exclusion Criteria

•serious complications associated with other systems;
•severe cardiac insufficiency;
•renal failure;
•body mass index (BMI) greater than 30 kg/m2 or less than 18 kg/m2;
•the use of low tidal volume and consequent hypercapnia can induce harm;
•refusal to participate in the study.

Key Dates

Start Date

October 8, 2023

Primary Completion Date

November 30, 2024

Completion Date

December 30, 2024

Last Updated

September 21, 2023

Enrollment

130

ESTIMATED participants

Conditions

TrendelenburgNeumoperitoneumOxygenationRespiratoryPulmonary

Interventions

group L (Vt 6 ml/kg)

OTHER

group I (Vt 8 ml/kg)

OTHER

Platform of Randomized Adaptive Clinical Trials in Critical Illness

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 21, 2023Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Different Tidal Volume on Oxygenation, Respiratory Mechanics, and Pulmonary Complications in Older Patients Undergoing Trendelenburg Pneumoperitoneum Surgery

Inclusion Criteria

Exclusion Criteria

Platform of Randomized Adaptive Clinical Trials in Critical Illness

Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients

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"Continuous Positive Airway Pressure on Venovenous extracorporeaL Membrane Oxygenation for Acute respIratory Distress syndrOme"