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Firefighter Thermoregulatory Responses in Active Fire with Betaine Supplementation | Clinical Trials | Clareo Health

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Firefighter Thermoregulatory Responses in Active Fire with Betaine Supplementation

Thermoregulatory Responses of Betaine Supplementation in Firefighters During Live Burn

NCT06042270•Michael J. Ormsbee

Summary

The goal of this clinical trial is to compare betaine supplementation to placebo in firefighters undergoing live burn training regarding thermoregulation and inflammation. The main questions it aims to answer are: * Does betaine supplementation mitigate rises in core temperature during firefighter live burn training? * Does betaine supplementation decrease inflammation from firefighter training? * Does betaine supplementation increase total body water stores? Participants will supplement with betaine for 1 month and complete: * Total Body Water measures * Body Composition measures * Live Burn training with Core Temperature Measurements * Provide Salivary samples

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Structural Firefighter

Exclusion Criteria

•• Participants have a cardiometabolic disease for which they take prescribed medications
•* Participants consume supplements known to impact hydration status or performance that they are not willing to stop taking for the study
•* Participants are pregnant
•* Female participants that have irregular menstrual cycles
•* Participants are injured and would not be able to fulfill the live burn scenario
•* Participants have sickle cell disease
•* Participants have experienced heat stroke within the last 2 years

Locations (1)

Institute of Sports Science and Medicine

Tallahassee, Florida, United States

Key Dates

Start Date

December 20, 2023

Primary Completion Date

March 1, 2024

Completion Date

September 1, 2024

Last Updated

October 17, 2024

Enrollment

ACTUAL participants

Conditions

Body Temperature ChangesBody Water DehydrationInflammation

Interventions

Betaine

DIETARY_SUPPLEMENT

Placebo

DIETARY_SUPPLEMENT

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 17, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Firefighter Thermoregulatory Responses in Active Fire with Betaine Supplementation

Inclusion Criteria

Exclusion Criteria

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