A US Study to Evaluate Transarterial Radioembolization (TARE) in Combination With Durvalumab and Bevacizumab Therapy in People With Unresectable Hepatocellular Carcinoma Amenable to TARE

Inclusion Criteria

• •Participants with confirmed unresectable HCC
• •Participants with Lung dose threshold for Yttrium 90 glass microspheres of 30 Gy (equal or less than 30 Gy per treatment for glass) and an estimated Future liver remnant volume (FLRV) ≥ 30% of whole liver volume.
• •Participants with more than 1 prior embolization are permitted if more than 12 months ago, for a different primary lesion, and FLR \> 30%.
• •Participants with no evidence of extrahepatic disease on any available imaging
• •Participants with one or more measurable lesions, unilobar disease for participants with segmental or right anterior/posterior portal vein invasion (Vp1/Vp2) and eligible for Yttrium 90 glass microspheres TARE.
• •Participants having Child-Pugh score class A.
• •Participants having ECOG performance status of 0 or 1 at enrollment
• •Adequate organ and marrow function
• •Participants co-infected with HBV and HDV
• •Any history of nephrotic or nephritic syndrome.
• +8 more criteria