129Xe MRI Cardiopulmonary

Inclusion Criteria

• •1. Outpatients of either gender, age \> 18
• •2. Willing and able to give informed consent and adhere to visit/protocol (Consent must be given before any study procedures are performed.)
• •3. Subject has no diagnosed pulmonary conditions
• •4. Subject has not smoked in the previous 5 years
• •5. Smoking history, if any, is less than or equal to 5 pack-years
• •6. No history of using other inhaled products more than 1/week for \> 1 year
• •1. In-patient or outpatients of either sex, age \> 18
• •2. Willing and able to give informed consent and adhere to visit/protocol
• •And one of the following:
• •1. Patients who are scheduled to receive a red cell transfusion for anemia.
• •2. Patients who are scheduled to undergo therapeutic phlebotomy to treat erythrocytosis or polycythemia
• •1. In-patient or outpatients of either sex, age \> 18
• •2. Willing and able to give informed consent and adhere to visit/protocol
• •And one of the following categories (ILD, Dyspnea, CTEPH, or Healthy):
• •1. Interstitial Lung Disease or Dyspnea
• •* Physician diagnosis of Interstitial Lung Disease by a pulmonologist using established criteria or physician referral of patient with dyspnea
• •OR
• •2. Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
• •* Patients with a diagnosis of CTEPH, defined as mean PA pressure \>20 mmHg with a pulmonary vascular resistance \>2 WU and pulmonary capillary wedge pressure ≤15 mmHg at right heart catheterization with evidence of chronic thromboembolic disease on clinical imaging after 3 months of anticoagulation
• •* Scheduled for pulmonary thromboendoarterectomy (PTE) surgery and willing to re-turn 3-6 months after for optional follow-up scans
• •OR
• •3. Healthy Volunteer (criteria noted above)
• •1. In-patient or outpatients of either sex, age \> 18
• •2. Willing and able to give informed consent and adhere to visit/protocol
• •And one of the following categories (Acute or Chronic)
• •1. Acute Pulmonary Embolism
• •* Patients presenting with acute PE 24-48hrs post-admission
• •* Willing to return after 3-6 months of anti-coagulation therapy
• •OR
• •2. Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
• •* Patients with a diagnosis of CTEPH, defined as mean PA pressure \>20 mmHg with a pulmonary vascular resistance \>2 WU and pulmonary capillary wedge pressure ≤15 mmHg at right heart catheterization with evidence of chronic thromboembolic disease on clinical imaging after 3 months of anticoagulation
• •* Scheduled for pulmonary thromboendoarterectomy (PTE) surgery and willing to re-turn 3-6 months after for optional follow-up scans