Clinical Study of Implants With Modified Surface Treatment

Exclusion Criteria

• •Pregnant or lactating women
• •Women of childbearing potential, unless she uses effective birth control until the completion of the final radiological examination, and for another 4 weeks after that.
• •A disease (including, but not limited to metabolic, hematological, kidney, liver, lung, neurological, endocrine, cardiac, infectious and gastrointestinal disease), which -in the opinion of the investigator- significantly affects the health of the examined person and/or exposes to an unacceptably high risk the person receiving the implantation treatment.
• •Malignant disease in the medical history in the preceding 24 months.
• •Known HIV, hepatitis B or hepatitis C, or any other considered viral infection relevant by the examiner known at the tome of randomization
• •A medical or psychiatric illness which, in the opinion of the investigator, excludes that the participant adheres to the protocol, or complete the study according to the protocol.
• •Participation in an other interventional clinical study within 6 months prior to treatment.
• •Known allergy to the implant or to the invetigational template or any of its components.
• •Limitation of mouth opening, which make unpossible to complete the procedure, based on the opinion of the investigator
• •Increased pharyngeal reflex, reduced ability to tolerate intraoral manipulation
• •Radiotherapy, previous irradiation of the jawbones
• •INR \> 2.5
• •Immunosuppressed patient
• •previous or current bisphosphonate treatment
• •Known alcohol or drug abuse
• •Heavy smoking (≥ 20 cigarettes per day, or another form of smoking, used in an equivalent amount)
• •Untreated periodontitis
• •Local infection of the implant in the planned area
• •Lack of dental hygiene, e.g. not removed radixes, plaque and calculus, or radiologically detectable potential periapical focus (also in asymptomatic case )
• •Insufficient or poor oral hygiene
• •Transient infectious state, with or without fever