Pausing Antiretroviral Treatment Under Structured Evaluation

Inclusion Criteria

• •Step 1:
• •Ability and willingness of participant to provide informed consent.
• •HIV-1 infection, documented by:
• •* Any licensed rapid HIV test or HIV enzyme or chemiluminescence immunoassay (E/CIA) test kit at any time prior to study entry AND
• •* Confirmed by one of the following:
• •* A second antibody test from different manufacturers or based on different principles and epitopes (combination antigen-antibody-based rapid tests may be used)
• •* HIV-1 antigen, or
• •* Plasma HIV-1 RNA viral load, or
• •* A licensed Western blot \[NOTE: The term "licensed" refers to a U.S. FDA-approved kit.\]
• •On stable suppressive ART for at least 96 weeks prior to study entry. \[NOTE: ART interruptions of up to 7 days occurring ≥90 days prior to study entry are acceptable. Within- and between-class changes in ART within the year prior to study entry are acceptable.\]
• •Plasma HIV-1 RNA levels of \<50 copies/mL for at least 96 weeks prior to study entry at any licensed local laboratory or Network-approved non-US laboratory that is VQA certified.
• •\[NOTE: Two "blips" (i.e., plasma HIV-1 RNA \>50 and \<400 copies/mL) are allowed if each blip is preceded and followed by values \<50 copies/mL. At least one viral load measurement in greater than 56 days and within 48 weeks prior to the entry visit and another viral load within 56 days prior to the entry visit must be available for review. \]
• •CD4+ cell count \>450 cells/µL obtained within 56 days prior to study entry at any Network-approved non-US laboratory that is IQA certified.
• •The following laboratory values obtained within 56 days prior to study entry by any Network-approved non-US laboratory that is EQA certified:
• •* Absolute neutrophil count (ANC) ≥750/mm3
• •* Hemoglobin ≥10 g/dL for participants who were assigned female sex at birth, ≥11.0 g/dL for participants who were assigned male sex at birth
• •* Platelet count ≥100,000/mm3
• •* Estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73m2 as calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-Epi) equation
• •* ALT \<2.5 times the institutional upper limit of normal
• •* Direct bilirubin within the institutional range of normal
• •For participants who can become pregnant (i.e., participants assigned female sex at birth who have not been post-menopausal for at least 24 consecutive months, who have had menses within the preceding 24 months, or who have not undergone surgical sterilization, specifically hysterectomy and/or bilateral oophorectomy or bilateral salpingectomy), negative serum or urine pregnancy test within 24 hours prior to Step 1 entry (Day 0) by a Network-approved non-US laboratory that is EQA certified. \[NOTE: Participant-reported history is acceptable documentation of hysterectomy and bilateral oophorectomy, tubal ligation, tubal micro-inserts.\]
• •Participants who can become pregnant must agree to use two methods of contraception, one of which must be from the highly effective methods for contraception listed below. Barrier methods of contraception are permitted for the second method of contraception. Contraception must be used from 10 days prior to study entry and participants must agree to use contraception for 36 weeks after receiving study treatment, and until ART is reinitiated and viral suppression is achieved. Acceptable methods of contraception include:
• •* Contraceptive subdermal implant
• •* Intrauterine device or intrauterine system
• •* Combined estrogen and progestogen oral contraceptive
• •* Injectable progestogen
• •* Contraceptive vaginal ring
• •* Percutaneous contraceptive patches
• •* Partner sterilization with documentation of azoospermia prior to the participant's entry into the study, and this partner is the sole partner for that participant. The documentation of partner sterility can come from the site personnel's review of medical records, medical examination and/or semen analysis, or medical history interview provided by the participant or the partner. Self-reported documentation of reproductive potential should be entered in the source documents.
• •Participants who can impregnate (i.e., individuals assigned male sex at birth who have not undergone a sterilizing procedure) a partner and who are engaging in sexual activity that could lead to pregnancy must agree to use condoms from 10 days prior to study entry and for 36 weeks after receiving study treatment to avoid impregnating a partner.
• •Willingness to use barrier protection (i.e., external or internal) for all sexual activity during ATI and until viral suppression is achieved after re-starting ART.
• •Willingness to not participate in other research studies of investigational drugs while on this study.
• •Willingness to provide a specimen for a genetic test (HLA Typing).
• •Step 2:
• •Participant who has completed Step 1, including receipt of both bNAb infusions, and has not met ART restart criteria described in the protocol at any time during Step 1.
• •Willingness to continue ATI and be monitored.
• •Step 3:
• •Meeting one or more ART restart criteria described in the protocol OR
• •Despite completing 72 weeks of ATI without meeting one or more ART restart criteria, participant declines participation in A5385, or is unable to enter A5385.