Glutamine Combined With Thalidomide in Preventing Radiation-induced Oral Mucositis

Inclusion Criteria

• •1. Age 18 to 75 years old;
• •2. Patients with postoperative oral malignant tumors confirmed by pathological histology or cytology and requiring radiotherapy;
• •3. Patients who have received more than 45Gy of radiation in the oral area;
• •4. ECOG PS (Eastern Cooperative Oncology Group Performance Status) score of 0-1;
• •5. Basic hematological indicators are normal: White blood cell count ≥ 4×10\^9/L; Absolute neutrophil count ≥ 1.5×10\^9/L; Platelets ≥ 100×10\^9/L; Hemoglobin ≥ 90 g/L;
• •6. Basic renal function is normal: Serum creatinine ≤ 1.5×ULN (Upper Limit of Normal) or Creatinine Clearance Rate (CrCl) \> 60 mL/min (using the Cockcroft-Gault formula):
• •For women: CrCl = (140 - age) × weight (kg) × 0.85 / (72 × Scr mg/dl) For men: CrCl = (140 - age) × weight (kg) × 1.00 / (72 × Scr mg/dl)
• •7. Basic liver function is normal: Serum total bilirubin ≤ 1.5×ULN; AST (Aspartate Aminotransferase) ≤ 2.5×ULN; ALT (Alanine Aminotransferase) ≤ 2.5×ULN.
• •8. Signed written informed consent.