A Study of Hemp Hull WFI for IBS Diarrhea

Exclusion Criteria

• •1. Diabetes mellitus (type 1)
• •2. Diabetes mellitus type 2 if taking metformin or GLP-1 agonist treatment (exenatide, liraglutide, semaglutide)
• •3. Uncontrolled hypertension (with BP measured \>140/90mmHg in the CRTU)
• •4. BMI ≥40 kg/m2
• •5. Chronic NSAID use (\>1 day/week)
• •6. Use of oral antibiotics and NSAIDs for 2 weeks prior to and during the entire 21 day study period
• •7. Use of bile acid sequestrant for 1 week prior to and during the entire 21 day study period
• •8. Diagnosis of gastrointestinal diseases that are associated with inflammation such as inflammatory bowel diseases and celiac disease or gastrointestinal infection in the prior 4 weeks;
• •9. Prior intestinal or colonic resection; note prior cholecystectomy, appendectomy, and tubal ligation or hysterectomy will all be permissible for participation in the study
• •10. Participation in highly vigorous exercise such as running \>5 miles per day in week prior to the permeability test