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RECRUITINGNA

Effects of Lean Pork Loin Intake on Protein Homeostasis and Glucose Regulation in Prediabetic Adults

NCT06025292•University of Arkansas

Summary

We will be directly comparing a high-quality protein diet composed primarily of lean pork loin (PORK) to a lower-quality plant-based protein diet (PLANT) in individuals with prediabetes on muscle and whole-body protein turnover and glucose regulation.

Eligibility

Age

40 - 65 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1\. Males and females ages 40-65 years.
•2\. BMI 25 to ≤40 kg/m2 (or body fat % ≥25% in males or ≥36% in females)
•3\. Capable of providing informed consent.
•4\. COVID-19 negative and/or asymptomatic.
•5\. Willing to abstain from drinking alcohol or consuming marijuana and CBD products during the 4-day study meal period
•6\. HbA1c: 5.7-6.4% or fasting glucose 100-125 mg/dL

Exclusion Criteria

•1\. Participant who does not/will not eat animal protein sources.
•2\. Allergy to wheat, soy, or common ingredients in plant-based protein products.
•3\. Body mass index \<25 kg/m2 or \>40 kg/m2.
•4\. Hemoglobin \<10g/dL at screening.
•5\. Platelets \<150,000/uL at screening.
•6\. History of chemotherapy or radiation therapy for cancer in the 6 months prior to enrollment.
•7\. History of gastrointestinal bypass/reduction surgery.
•8\. Pregnant or lactating individuals.
•9\. History of a chronic inflammatory disease (e.g. Lupus, Crohn's disease)
•10\. Currently receiving androgen (e.g., testosterone) or anabolic (e.g., GH, IGF-I) therapy.
+7 more criteria

Locations (1)

University of Arkansas for Medical Sciences

Little Rock, Arkansas, United States

Key Dates

Start Date

September 11, 2024

Primary Completion Date

May 31, 2026

Completion Date

November 30, 2026

Last Updated

July 18, 2025

Enrollment

ESTIMATED participants

Conditions

Hyperglycaemia (Non Diabetic)Prediabetes

Interventions

Lean Pork vs Plant-Based Protein

OTHER

Contacts

David Church, PhD

CONTACT

501-526-5769 dchurch@uams.edu

Amanda Gwin, PA-C

CONTACT

5018380096 algwin@uams.edu

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: July 18, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Effects of Lean Pork Loin Intake on Protein Homeostasis and Glucose Regulation in Prediabetic Adults

Inclusion Criteria

Exclusion Criteria

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