Sponsors

Lead Sponsor

Imbrium Therapeutics

Collaborators

Purdue Pharma LP

Age

18 - 70 years

Sex

FEMALE

Healthy Volunteers

No

Inclusion Criteria

•1. Female, age ≥18-70 years and capable of voiding independently. Able to comply with acceptable methods of contraception.
•2. Has symptoms of overactive bladder including (OAB) urinary urgency and urinary frequency with incontinence for ≥3 months.
•3. Willing to modify current OAB treatment regimen.

Exclusion Criteria

•1. Significant stress incontinence or mixed stress/urge incontinence where stress is the predominant factor.
•2. Urinary tract infection (UTI) within past 30 days, or history of recurrent UTI.
•3. Hematuria associated with bladder malignancy or other significant pathology.
•4. Had surgical procedure that affected bladder function.
•5. Received intravesical therapy within past 12 months or had bladder hydrodistention within past 6 months.
•6. Grade III/IV pelvic organ prolapse with/without cystocele or urethral diverticulum.
•7. Clinically significant kidney disease or nephrolithiasis.

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