Can (Optical Coherence Tomography) Pictures of the Retina Detect Alzheimer's Disease at Its Earliest Stages?

Inclusion Criteria

• •By clinician (or prior research) assessment, known to either be cognitively normal, or have mild cognitive impairment
• •Known Alzheimer's biomarker status. As of 2023-JUL, this must either be an amyloid PET scan, or cerebrospinal fluid measurement of amyloid and tau levels.
• •NOTE: Although this is a study of the eyes, age-typical ocular/vision complaints are permissible, so long as the the retina is thought to be healthy. This list of acceptable conditions includes most people who:
• •* wear glasses
• •* wear contacts
• •* use over-the-counter eye drops
• •* have mild cataracts (no surgery scheduled)
• •* had cataracts removed
• •* had eye muscle surgery (e.g., to correct eye misalignment)
• •* had eyelid surgery (blepharoplasty)
• •* are monitored by an ophthalmologist in case a problem with the retina develops (this is sometimes suggested for people with diabetes), but one or both retinas is/are thought to be completely healthy