This is an interventional pharmacokinetic study comparing the uptake and metabolism of nicotine from smoke-exposed clothing in people with low high levels of dermal melanin and people with high levels of dermal melanin. The study will measure nicotine and metabolites of nicotine in the blood during exposure and in urine for 10 days after exposure.
Age
18–50
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Adult nonsmoker
Aged 18-50
Skin reflectance scores below 150 or above 249 using the Mexameter 18 instrument
Healthy on the basis of medical history
Systolic blood pressure \<150
Diastolic blood pressure \<100
C-reactive protein \<3.1 mg/ml
Liver function (AST and ALT) in normal ranges
kidney function (BUN) in normal ranges
LDL\<131
Blood glucose \<110
Not exposed to tobacco SHS.
You may not be if
Dermal skin reflectance score between 150 and 249, as measured by the Mexameter 18 instrument.
Positive SARS-CoV-2 antibody test
Age 18 \< or \> 50
Physician diagnosis of asthma, heart disease, hypertension, thyroid disease, diabetes, renal or liver impairment or glaucoma.
Unstable psychiatric condition (such as current major depression, history of schizophrenia or bipolar disorder) or current use of more than two psychiatric medications
Systolic blood pressure greater than or equal to 150
Diastolic blood pressure greater than or equal to 100
Blood glucose greater than or equal to 110
LDL greater than or equal to130
Pregnancy or breastfeeding (by urine hCG and/or history)
Alcohol or illicit drug dependence within the past 5 years
BMI \> 35 and \< 18
Current illicit drug use (by history or urine test)
More than 1 pack year smoking history
Ever a daily marijuana smoker
Smoked anything within the last 3 months
Unable to hold allergy or other OTC medicines
Occupational exposure to smoke, dusts OR fumes
Concurrent participation in another clinical trial
Unable to communicate in English
No social security number
Clareo Health | Melanin and Dermal Uptake of Thirdhand Cigarette Smoke
