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COMPLETEDNA

Effects of Early and Late Time-restricted Eating on Overweight Adults With Metabolic Syndrome

NCT06018415•First Affiliated Hospital Xi'an Jiaotong University

Summary

Investigators aim to compare the effects of early and late time-restricted feeding on overweight adults with metabolic syndrome

Eligibility

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Age from 18 to 65 years
•2. Body mass index (BMI): 24.0-40.0 kg/m2
•3. Diagnosed with metabolic syndrome (i.e., more than 3 abnormal findings out of 5):
•1. Waist circumference ≥ 90 cm (men) or ≥ 80 cm (women).
•2. Elevated triglyceride (TG) (use of lipid-lowering medication is an alternate indicator) ≥ 150 mg/dL (1.7 mmol/L).
•3. Reduced high-density lipoprotein cholesterol (HDL-c) (use of lipid-lowering medication is an alternate indicator) \< 40 mg/dL (1.0 mmol/L) in males \< 50 mg/dL (1.3 mmol/L) in females.
•4. Elevated blood pressure (use of antihypertensive medication is an alternate indicator). Systolic blood pressure (SBP) ≥ 130 and/or diastolic blood pressure (DBP) ≥ 85 mmHg.
•5. Elevated fasting blood glucose (FBG) (used of hypoglycemic medications is an alternate indicator) ≥ 100 mg/dL (5.6 mmol/L).

Exclusion Criteria

•1. Unstable weight (change \> 10% current body weight) for 3 months prior to the study
•2. Pregnant or breast-feeding
•3. Night shift workers
•4. History of major diseases or related diseases, such as cancer, inflammatory disease, chronic obstructive pulmonary disease and major adverse cardiovascular event
•5. Active viral hepatitis, acquired immune deficiency syndrome, syphilis and other sexually transmitted diseases, tuberculosis and other infectious diseases
•6. Being treated with antibiotics or corticosteroids
•7. Current participate in other weight-management program, current on a prescribed diet for special disease or current on any drugs that effect appetite
•8. The researcher deemed it inappropriate to participate in the experimenter.

Locations (1)

First Affiliated Hospital of Xi 'an Jiaotong University

Xi'an, Shaanxi, China

Key Dates

Start Date

May 7, 2024

Primary Completion Date

October 16, 2024

Completion Date

October 16, 2024

Last Updated

December 22, 2025

Enrollment

103

ACTUAL participants

Conditions

Metabolic SyndromeOverweight and ObesityTime Restricted Eating

Interventions

Early time-restricted eating (eTRE)

BEHAVIORAL

Late time-restricted eating (lTRE)

BEHAVIORAL

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 22, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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Effects of Early and Late Time-restricted Eating on Overweight Adults With Metabolic Syndrome

Inclusion Criteria

Exclusion Criteria

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