Clément Brault, MD

CONTACT

Lead Sponsor

Centre Hospitalier Universitaire, Amiens

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•Consecutive adult patients (≥18 years old) undergoing mechanical ventilation for at least 24h (regardless of the reason of intubation)
•patients fulfilling criteria for an SBT
•patients will have to be able to trigger ventilator breaths with a reasonable level of assistance,
•patients with lack of severe impairment in gas exchange,
•patients that not require significant hemodynamic support.
•Patients will be recruited by the study coordinator following completion of informed consent from the patient or legally authorized substitute decision maker.

•Use of pressure support during the SBT.
•Severe hemodynamic instability (\>30% increase in vasopressors in the last 6 hours or norepinephrine \> 0.5 µg/kg/min).
•Severe or very severe chronic obstructive pulmonary disease (COPD) according to the GOLD criteria (stage III: FEV1 30-50% predicted; stage IV: FEV1 \< 30% predicted).
•Known or suspected severe or progressive neuromuscular disorder likely to result in prolonged or chronic ventilator dependence
•Clinical judgement of the attending physician.