GLUCOSE-MGH: Genetic Links Understood Through Challenge With Oral Semaglutide Exposure at MGH

Exclusion Criteria

• •1. Currently taking medications or intending to take medications for diabetes
• •2. Currently taking medications or intending to take medications that affect glycemic parameters, such as glucocorticoids, growth hormone, or fluoroquinolones
• •3. Personal history of intestinal malabsorption, bariatric surgery, celiac disease, gallbladder disease, or pancreatitis
• •4. Personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2
• •5. Estimated glomerular filtration rate (eGFR) \<60 ml/min/1.73 m2 per the Modification of Diet in Renal Disease equation
• •6. History of cirrhosis and/or aspartate aminotransferase or alanine aminotransferase more than 3x upper limit of normal
• •7. Dietary restrictions preventing consumption of a MMTT
• •8. Women who are pregnant, nursing, or at risk of becoming pregnant
• •9. Participation in other interventional studies during the current study