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RECRUITINGNA

Cleaner Air for Lower Cardiometabolic Risk

Glycemic and Cardiometabolic Biomarker Improvements Associated With Reduction in Air Pollution Exposure

NCT05994937•NYU Langone Health

Summary

The purpose of this interventional sham-controlled pilot study is to study the effects of using portable air cleaners (PACs) in outpatient adults with prediabetes. The primary aims are to determine the effect PAC's have on glycemic variability and the concentrations of circulating biomarkers of inflammation.

Eligibility

Age

18 - 85 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Participant is ≥18 years old
•Participant and members of household are reported to be non-smokers (defined as no household members are currently known to smoke cigarettes or use other tobacco products including e-cigarettes)
•Participant is to understand/speak English or Spanish
•Participant can understand study procedures and give informed consent
•Participant has prediabetes, defined as the absence of diabetes and any of the following: fasting plasma glucose 100-125 mg/dL, 2 hour plasma glucose of 140-199 mg/dL after 75 g oral glucose tolerance test, or A1c 5.7- 6.4%.
•Able to wear CGM for 2 two-week periods
•Able to participate in telephone or video conference for home equipment setup if needed
•Able to visit clinic for blood draws before and after the study period
•Do not intend to sleep anywhere outside of primary bedroom for more than 48 consecutive hours or a total of 7 days during the study period.
•Ability to lift, or access to assistance with lifting, 20 lb to set up air filter appliance in bedroom.
+1 more criteria

Exclusion Criteria

•Participants who have diagnosed diabetes, or take antihyperglycemic medications
•Participants with known atherosclerotic disease: coronary artery disease, peripheral artery disease or history of cerebrovascular disease (stroke or Transient Ischemic Attack (TIA), carotid stenosis)
•Participants with known systemic inflammatory conditions (including but not limited to: inflammatory arthritis, vasculitides, inflammatory bowel diseases, cancer within past 5 years, Hashimoto's thyroiditis)
•Participants currently taking any anti-inflammatory medications or medications that target inflammatory cytokines
•Pregnancy: because blood glucose problems during pregnancy require intensive monitoring and lifestyle changes to protect the mother and fetus
•Participants with known or suspected Covid-19 in the prior 30 days
•Participants with post-covid sequelae (a.k.a "Long covid")
•Participants who are already utilizing HEPA filtration (PAC or within HVAC) in bedrooms

Locations (1)

NYU Langone Medical Center

New York, New York, United States

Key Dates

Start Date

December 26, 2023

Primary Completion Date

February 28, 2026

Completion Date

February 28, 2026

Last Updated

December 22, 2025

Enrollment

160

ESTIMATED participants

Conditions

PreDiabetes

Interventions

PAC with HEPA filter intact

DEVICE

PAC with HEPA filter removed

DEVICE

Contacts

Sharine Wittkopp

CONTACT

646-501-8121 Sharine.Wittkopp@nyulangone.org

Jonathan Newman

CONTACT

212-263-9393 Jonathan.Newman@nyulangone.org

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 22, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Cleaner Air for Lower Cardiometabolic Risk

Inclusion Criteria

Exclusion Criteria

Pharmacogenetics of the Response to GLP-1 in Mexican-Americans With Prediabetes

Rural Alliance for Diabetes Prevention

Human Immunodeficiency Virus (HIV) Food Insecurities

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