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Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial | Clinical Trials | Clareo Health

RECRUITINGNA

Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial

NCT05991453•Washington University School of Medicine

View on ClinicalTrials.gov

Summary

The investigators will conduct a 13,000-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major inpatient surgery, (b) minor inpatient surgery, (c) outpatient surgery) and (ii) whether TIVA confers no more than a small (0.2 %) increased risk of intraoperative awareness than INVA in patients undergoing both outpatient and inpatient surgeries

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Each patient must meet all of the following criteria:
•1. Aged 18 years or older
•2. Undergoing elective non-cardiac surgery expected to last ≥ 60 min requiring general anesthesia with a tracheal tube or laryngeal mask airway (or similar supra-glottic device)

Exclusion Criteria

•Patients will not be enrolled if any of the following criteria are met:
•1. Inability to provide informed consent in English (at all study sites) or Spanish (at sites where Spanish consent is provided as an option)
•2. Pregnancy (based on patient report or positive test on the day of surgery)
•3. Surgical procedure requiring general, regional, neuraxial anesthesia administered by an anesthesia clinician (anesthesiologist, CRNA, anesthesiology assistant) occurring within 30 days prior to or planned to occur within 30 days after surgery date
•4. Contraindication to propofol TIVA or INVA (for example, documented allergy to propofol, history of severe postoperative nausea or vomiting, concern for or history of malignant hyperthermia) based on self-report
•5. Surgical procedures requiring a specific general anesthesia technique (for example, TIVA required for neuromonitoring).
•6. Locally approved, written protocol mandating a particular anesthetic technique
•7. History of possible or definite intraoperative awareness during general anesthesia based on patient self-report
•8. Planned postoperative intubation
•9. Current incarceration

Locations (20)

University of Arkansas for Medical Sciences (UAMS)

Little Rock, Arkansas, United States

University of California San Francisco

San Francisco, California, United States

Stanford University

Stanford, California, United States

Yale School of Medicine

New Haven, Connecticut, United States

Massachusetts General Hospital

Boston, Massachusetts, United States

Brigham & Women's

Boston, Massachusetts, United States

University of Michigan

Ann Arbor, Michigan, United States

Henry Ford Health

Detroit, Michigan, United States

Washington University School of Medicine

St Louis, Missouri, United States

Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, United States

Key Dates

Start Date

September 13, 2023

Primary Completion Date

July 31, 2027

Completion Date

July 31, 2028

Last Updated

August 5, 2025

Enrollment

13,000

ESTIMATED participants

Conditions

Surgery-ComplicationsAnesthesia ComplicationAnesthesia AwarenessAnesthesiaSurgeryQuality of LifePain, PostoperativeAnesthesia Morbidity

Interventions

Anesthetic technique Propofol TIVA

OTHER

Anesthetic technique inhaled agent

OTHER

Contacts

Laura Swisher

CONTACT

314-286-1024 goodl@wustl.edu

Sherry McKinnon

CONTACT

314-286-1024 smckinnon@wustl.edu

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: August 5, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial

Inclusion Criteria

Exclusion Criteria

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