A Study to Evaluate the Safety and Immunogenicity of ChAdOx1-VZV in Healthy Adults Aged 50-65 Years

Exclusion Criteria

• •Pregnant or lactating at screening or planning to become pregnant (self or partner) at any time during the study, including the follow-up period
• •History of severe allergic reaction (e.g., anaphylaxis) to any component of the vaccine.
• •History of herpes zoster (HZ) (Shingles) in the past 5 years.
• •Previous vaccination against HZ.
• •History of or present substance abuse as judged by the investigator.
• •Immunosuppression resulting from hematopoietic stem cell transplantation, acquired immunodeficiency syndrome (AIDS) or symptomatic (human immunodeficiency virus) HIV infection.
• •Chronic administration of immunosuppressants (at least 10 mg per day of prednisone equivalent for glucocorticoids) or other immune-modifying drugs within 6 months prior to the first dose of investigational vaccine.
• •Has received any blood products or immunoglobulin within 90 days prior to study injection, or is likely to require infusion of blood products during the study period.
• •Is undergoing chemotherapy or expected to receive chemotherapy during the study period; has a diagnosis of or receiving treatment for cancer within the last 5 years.
• •History of clinically significant thrombocytopenia or other clotting disorders.
• •Serious cardiovascular disease (pulmonary heart disease, pulmonary edema, hypertension that cannot be controlled by medication (systolic blood pressure \> 160 mmHg and/or diastolic blood pressure \> 100 mmHg)), serious liver and kidney disease, and diabetes mellitus with complications.
• •History of allergic skin diseases.
• •Use of any investigational or non-registered product (drug or vaccine) within 30 days before the first dose of investigational vaccine/product, or planned use during the study period.
• •Receipt of any other immunizations within one month before the first dose of investigational vaccine (2 weeks in the case of inactivated influenza vaccines or other non-replicating immunization products \[e.g., tetanus and reduced dose diphtheria toxoid (dT) vaccine, pneumococcal vaccine, hepatitis A vaccine, hepatitis B vaccine\]), or scheduled within 30 days after last dose of investigational vaccine.
• •Received a vaccine with adenovirus vector within 6 months prior to the first dose of investigational vaccine.
• •Investigator site staff directly involved in the conduct of the study, site staff otherwise supervised by the investigator, and their respective family members.
• •Volunteers with or have history of lung function abnormalities such as asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis.
• •Current smokers.
• •History or current evidence of any condition, therapy, or laboratory abnormal values that are clinically significant which might confound the results of the study, interfere with the participant's participation for the full duration of the study, or is not in the best interest of the participants to participate, in the opinion of the treating investigator.