Shuo Wang

CONTACT

Lead Sponsor

Beijing Tiantan Hospital

Collaborators

Age

18 - 75 years

Sex

ALL

Healthy Volunteers

No

•(1) 18-75 years old;
•(2) non-traumatic intracerebral hemorrhage;
•(3) severe intracerebral hemorrhage, which was defined as patients with supratentorial bleeding volume \> 30 ml, infratentorial bleeding volume \> 10 ml, midline shift \> 1 cm, or large intraventricular hematoma;
•(4) Glasgow coma score (GCS) \< 13;
•(5) family members agree to provide an informed written consent.

•(1) patients had cerebrovascular diseases, e.g., intracranial aneurysm or vascular malformation, and intracranial tumors, which were associated with hemorrhage;
•(2) hemorrhagic transformation of cerebral infarction;
•(3) hemorrhage caused by venous thrombosis;
•(4) patients with severe coagulation disorder, e.g., hemophilia;
•(5) patients with coagulation dysfunction caused by malignant tumor, hepatic insufficiency, renal dysfunction, thrombocytopenia, coagulation diseases, and so on;
•(6) patients receiving other anticoagulation medications (vitamin K antagonist and new oral anticoagulants);
•(7) patients not on LOAPT who receive conservative treatment;
•(8) the patients who died before or on arriving at the hospital and within a short period (6 h) after admission.