A Phase I/II Clinical Study in Patients with Advanced Solid Tumor.

Exclusion Criteria

• •Subjects will be excluded from the study based on the following criteria:
• •1. Imaging examination suggests intracranial metastasis, which requires local treatment (in case of asymptomatic or symptomatic brain metastasis requiring no local treatment based on the investigator's judgement, the subject can still be included), or currently taking steroid hormone prior to inclusion, such as \>10 mg prednisone (or equivalent) for intracerebral edema from brain metastases; subjects with meningeal carcinomatosis will be excluded regardless of their clinical stability
• •2. History of previously received major surgery or surgical therapy for any cause within 4 weeks of the first dose; radiotherapy, chemotherapy, other clinical trial drugs or other anti-tumor treatment, within 5 half-lives or 3 weeks (whichever is shorter), prior administering the first dose of study drug on Day 1
• •3. History of previous treatment with ATR inhibitors or other DDR related inhibitors (except poly ADP ribose polymerase enzyme (PARP) inhibitors)
• •4. Subjects with a history of another primary malignancy other than:
• •1. carcinomas in situ, (e.g., breast, cervix, and prostate)
• •2. Locally excised non-melanoma skin cancer
• •3. No evidence of disease from another primary cancer for two or more years and has not taken any anti-cancer treatment in two years. Exceptions are gonadotropin-releasing hormone (GnRH) therapy for prostate cancer and hormonal maintenance therapy for breast cancer.
• •5. Previously received treatment with strong CYP3A4, CYP2C8 and P-gp inhibitors or strong CYP3A4, CYP2C8 and P-gp inducers within 14 days prior to the first medication
• •6. Patients with AE due to previous anti-tumor treatment that has not recovered to ≤ CTCAE grade 1 (except for alopecia, pigmentation and lymphopenia)
• •7. Patients who are unable to swallow the tablets normally, or have abnormal gastrointestinal function that may affect the drug absorption, such as malabsorption syndrome or major resection of the stomach or bowels based on the judgment of the investigator
• •8. Subjects with any severe and/or uncontrolled disease, including:
• •1. Poor blood pressure control (systolic blood pressure ≥ 150 mmHg or diastolic blood pressure ≥ 100 mmHg)
• •2. Myocardial infarction, arrhythmia (CTCAE grade 2 and above, also including ≥ Class II congestive heart failure (CHF) (New York Heart Association (NYHA) classification) (refer to Appendix-A)
• •3. Active infection or fever of unknown origin ≥ 38.5℃ within 7 days prior to the first medication
• •4. Active viral hepatitis; positive hepatitis B surface antigen and/or hepatitis B core antibody and measured HBV DNA value ≥ 500 IU/ml; positive HCV antibody and measured HCV titer exceeding the upper limit of normal;
• •5. Positive Treponema pallidum antibody;
• •6. History of immunodeficiency, including positive HIV antibody or other acquired or congenital immunodeficiency diseases, or history of organ transplant;
• •7. Poor control of diabetes (fasting blood glucose (FBG) \> 10 mmol/L);
• •8. Liver disease such as decompensated liver disease
• •9. Uncontrolled pleural effusion, pericardial effusion, or peritoneal effusion as per the investigator opinion
• •10. Patients with clinically significant hemorrhage symptoms or bleeding tendency within 3 months prior to the first study medication
• •11. Known hypersensitivity or contraindication to any drug or any of the components of investigational product
• •12. Any other clinically significant acute or chronic medical or psychiatric or any laboratory abnormality that may increase the risk associated with study drug administration or may interfere with the interpretation of study results