Role of Curcumin in Paclitaxel Induced PN

The work is a prospective, randomized, open label controlled study. A total of 90 breast cancer female patients will be enrolled in the study. Eligible patients will simply be randomized using random allocation generator, after the end of anthracycline adjuvant therapy to one of two groups, Group I: will receive paclitaxel regimen plus 2g of curcumin Group II: will receive paclitaxel regimen only. The cases involved in the study will be recruited from Ain Shams Teaching Hospital. All patients presenting to the department were assessed for eligibility according to certain inclusion and exclusion criteria. Details of the research steps that the subscriber will be exposed to: * Base line evaluation then alignment in either intervention or control group either for taking the interventional drug or standard of care in control group. * Blood samples will be collected at baseline. * Patient will be given a weekly supply of the medication and will be asked to take his prescribed dose daily. * Every week all patients will be asked about their symptoms and if they experience any adverse drug reaction. * Patients will receive the interventional drug until the last paclitaxel dose will be taken. * After 3 months, another full clinical examination and blood sample will be obtained.