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Modified Urine Fetuin A as a Predictor of Deterioration of Renal Function in Patients With Resistant and Non-resistant Hypertension
Commonly used parameters (creatinine, estimated glomerular filtration rate, and urine albumin/creatinine ratio) for prediction of decline of renal function are sensitive for advanced kidney impairment. Modified human urine Fetuin A (urine Fetuin A) with specific modification in urine (Fetuin A) can earlier predict the progression of kidney disease in patients with diabetes. Studies evaluating urine Fetuin A in hypertonic patients are still lacking.
Arterial hypertension and diabetes are the most common cause of chronic kidney disease. Commonly used parameters for the evaluation of renal function (plasma creatinine, estimated glomerular filtration rate, and urine albumin/creatinine ratio) are sensitive to advanced kidney disease. Parameters predicting early kidney impairment are still lacking. Modified human urine Fetuin A with specific modification in urine (urine Fetuin A) presents a new biomarker that seems to be promising in the early prediction of kidney disease in patients with diabetes without microalbuminuria. Studies evaluating urine Fetuin A in hypertonic patients are still lacking.
Age
18 - 100 years
Sex
ALL
Healthy Volunteers
No
University Hospital Ostrava, - Department of Internal Medicine and Cardiology
Ostrava, Czech Republic, Czechia
Start Date
July 1, 2023
Primary Completion Date
December 31, 2025
Completion Date
December 31, 2026
Last Updated
July 27, 2023
200
ESTIMATED participants
No intervention.
OTHER
Lead Sponsor
University Hospital Ostrava
NCT07218029
NCT06649110
Data Source & Attribution
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View ClinicalTrials.gov Terms and ConditionsNCT06481852