Right-handed volunteers, assessed by Edinburgh handedness inventory
Normal or corrected-to-normal vision
Greater than or equal to 18 years old
Relapsing-remitting type of MS (RRMS)
Moderate disability EDSS score ≤ 6.5
Free of relapsing attack at least a month before recruitment
You may not be if
Subject recently had a seizure or epilepsy
Subject is a habitual smoker;
Subject has a history of any major disease that may interfere with the investigations (especially liver and kidney disease, upper limb pathologies, history of significant multiple traumas, or diabetes) or cancer;
Subject has any history of a major neurological disorder in addition to MS (including previous severe brain trauma and cognitive impairment) or known cerebral structural abnormalities;
Subject has a diagnosed mental disorder (e.g., depression, bipolar disorder, schizophrenia, psychoses);
Subject is currently a user (including ''recreational use'') of any illicit drugs or has a history of drug or alcohol abuse;
Subject has significant abnormalities on T1/T2 MRI scan;
Subject has a contra-indication for MRI scanning or TMS measurements (see screening forms for MRI and TMS);
Subject does not understand the study procedure;
Subject is unwilling or unable to perform all study procedures, or is considered unsuitable in any way by the principal investigator;
Subject is not able to perform the motor tasks;
Subject is (potentially) pregnant (in case of doubt, hCG test will be conducted in female participants); subject is breastfeeding at the time of the study;
Subject chronically uses medication, especially sedatives or sleep medication (contraceptives allowed). Other medication that is only taken as needed will be allowed at the investigator's discretion;
Using TMS, no (sufficiently stable) MEPs can be evoked at left M1;
Clareo Health | Investigation The Effect of Conventional Vs. Individualized tDCS Intensity to Achieve Uniform E-Fields
