Loading clinical trials...

Insight Into Hippocampal Neuroplasticity in Schizophrenia by Investigating Molecular Pathways During Physical Training | Clinical Trials | Clareo Health

RECRUITINGNA

Insight Into Hippocampal Neuroplasticity in Schizophrenia by Investigating Molecular Pathways During Physical Training

NCT05956327•LMU Klinikum

View on ClinicalTrials.gov

Summary

Aerobic endurance training has shown positive effects on symptoms, cognition, daily functioning, and the structure of the hippocampus in patients with schizophrenia. The study investigates genetic and epigenetic influences on neuroplastic changes following three months of endurance training. A control group performs flexibility, strength, and balance training. The main objective is to examine the association between a genetic risk score for schizophrenia and volume increase in the CA4/DG region of the hippocampus. Additional goals include examining changes in synapses, brain structure, function, and metabolism, as well as clinical symptoms and cognitive performance.

Eligibility

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Written informed consent for voluntary study participation.
•Patients with schizophrenia: diagnosis of schizophrenic psychosis according to ICD10 and DSM V,
•Positive And Negative Syndrome Scale (PANSS) total score ≤ 75 before the start of the intervention
•Reliable contraception in women of childbearing age
•Patients must have been treated with individualized medication according to valid treatment guidelines. All antipsychotic substances are allowed, also as depot medication. Treatment with one as well as with two antipsychotic substances is possible. The additional administration of low- and medium-potency antipsychotic substances as on-demand medication for the treatment of agitation and sleep disorders is possible, provided that the daily dosage of 150 CPZ units is not exceeded. The active substance and dose of the individualized antipsychotic medication used to achieve the inclusion criterion of psychopathological symptom remission must be constant for at least 2 weeks before inclusion in the study.

Exclusion Criteria

•Lack of reliability and sanity (examined by an independent psychiatrist)
•Positive urine drug screen for illicit drugs (except benzodiazepines)
•Acute suicide risk
•Other relevant psychiatric axis-I disorders according to the diagnostic testing procedure (Mini International Neuropsychiatric Interview, MINI)
•Other relevant neurological or other disorders
•Pregnancy or lactation

Locations (1)

LMU Klinikum

Munich, Bavaria, Germany

Key Dates

Start Date

September 29, 2023

Primary Completion Date

September 1, 2026

Completion Date

September 1, 2026

Last Updated

November 21, 2023

Enrollment

156

ESTIMATED participants

Conditions

SchizophreniaNeuronal PlasticityExercise

Interventions

Aerobic Endurance Training

PROCEDURE

Flexibility, strengthening and balance training

PROCEDURE

Contacts

Isabel Maurus, Dr.

CONTACT

+49 89 4400 55537 Isabel.Maurus@med.uni-muenchen.de

Lukas Roell, M.Sc.

CONTACT

+49 89 4400 55812 Lukas.Roell@med.uni-muenchen.de

Sustaining Physical Activity After Cancer Exercise Sessions

NCT06359210

Exercise OncologyPhysical Activity Behavior+1 more

View study

RECRUITINGNA

Does the Development of the Repeated Bout Effect Depend on Oxidative Stress and Inflammation?

NCT07472244

Exercise Recovery

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 21, 2023Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Insight Into Hippocampal Neuroplasticity in Schizophrenia by Investigating Molecular Pathways During Physical Training

Inclusion Criteria

Exclusion Criteria

Sustaining Physical Activity After Cancer Exercise Sessions

Does the Development of the Repeated Bout Effect Depend on Oxidative Stress and Inflammation?

Feasibility of Integrating Street Racket Into Ambulatory Pulmonary Rehabilitation

Feasibility, Acceptability, and Preliminary Efficacy of Yoga-based Group Intervention for Outpatients With Schizophrenia Spectrum Disorders

Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services

A Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Inpatient Adults With Schizophrenia