Berberine on the Secretion of Incretin

Exclusion Criteria

• •1. Infection with hepatitis (A, B, or C), HIV and syphilis.
• •2. Those with clear allergy to berberine hydrochloride or its preparation components; those with drug (including salicylic acid) allergy, history of allergic diseases or allergic constitution.
• •3. Patients with hemolytic anemia and glucose-6-phosphate dehydrogenase deficiency.
• •4. Those who have used any prescription medication, herbal medicine within 4 weeks prior to dosing and/or taken over-the-counter medication (except for subjects with occasional or restricted use of paracetamol), supplements (except for routine vitamin supplementation) within 2 weeks prior to dosing.
• •5. Cumulative amount of blood loss (eg. blood donation) over 400mL within 3 months prior to baseline visit and during the study.
• •6. Heavy smokers (25 or more cigarettes per day) and heavy drinkers (14 units of alcohol per week, 1 unit = 285ml of beer, or 25ml of spirits, or 100ml of wine).
• •7. Those with a history of substance abuse or positive urine test for prohibited drugs.
• •8. Those who participated in any clinical trial within 1 month prior to the trial, or those who plan to participate in other clinical trials during or within 1 month after the end of the trial.
• •9. Other circumstances that the investigator considers unsuitable for participation in this study.