Lead Sponsor

Riphah International University

Age

20 - 70 years

Sex

ALL

Healthy Volunteers

No

•Patients with pulmonary arterial hypertension, not pregnant and tobacco free.
•Age = 21 to 82
•Patients with documented PAH diagnosed by echocardiography (enlarged RA an enlarged RV with a thick wall, septal shift by enlarged chambers of right side of heart, an elevated mPAP) or a resting mean pulmonary arterial pressure equal to 25mm Hg determined by right heart catheterization.
•Patients on stable PH therapies, sedentary, and had no pulmonary rehabilitation for 6 months prior to enrolment.

•Patients will be excluded if they are not able to complete 6MWT.
•A documented pulmonary capillary wedge pressure greater then or equal to 15 mm Hg.
•Significant hepatic, renal, metabolic or mitochondrial dysfunctions; severe psychiatric disease; use of beta-adrenergic blockers or antiretroviral therapies; and any musculoskeletal or neurological condition that would limit walking or exercise performance.
•Patients with a history of heart failure.