Vitamin K2 Supplementation in Adult Episodic Migraine

Exclusion Criteria

• •Migraine patients with superimposed tension type or other forms of primary headaches
• •Patients who are currently on any of the migraine prophylactic treatments (Sodium valproate, Topiramate, Beta-blockers, Tricyclic antidepressants, SRNI, Flunarizine, Verapamil, Lisinopril, Candesartan)
• •Patients who have been on any of the previously listed medications within 3 months of screening
• •Patient who takes the following medications:
• •* Ergotamine or Triptans \> 10 days per month
• •* NSAIDs or paracetamol \> 15 days per month
• •* Opioids more than 4 days per month
• •* Patients on anticoagulants
• •Other active chronic pain syndromes (i.e. fibromyalgia, painful peripheral neuropathy, post-herpetic neuralgia…)
• •History of hypersensitivity to the vitamin K2
• •History of soy protein, cheese, eggs and meat allergy
• •History of thrombotic events
• •Diagnosed coagulopathy or any condition related to coagulation
• •Cardiovascular event in the past month
• •Current or planned pregnancy
• •Lactation
• •Inability to tolerate oral medications
• •Known intestinal malabsorption or hypomotility syndromes
• •Atrial fibrillation
• •Active malignancy
• •Any acute illness in the past month