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Dexmedetomidine or Lidocaine for Lessening the Hemodynamic Responses to Laryngoscopy and Intubation | Clinical Trials | Clareo Health

COMPLETEDNA

Dexmedetomidine or Lidocaine for Lessening the Hemodynamic Responses to Laryngoscopy and Intubation

Comparing Intravenous Versus Nebulized Either Lidocaine or Dexmedetomidine for Attenuation of the Hemodynamic Responses to Laryngoscopy and Intubation

NCT05941767•Zagazig University

View on ClinicalTrials.gov

Summary

Laryngoscopy, tracheal intubation, surgical stimulation, and extubation unleash remarkable sympathetic activity and are associated with transient but significant hemodynamic changes. The need to blunt these noxious responses effectively has led to using several techniques and pharmacological agents, local anesthetics, beta-adrenergic-blockers, calcium channel antagonists, and opioids with varied success. This study aims to evaluate the effect of nebulized and intravenous either dexmedetomidine or lidocaine for attenuating the hemodynamic responses to laryngoscopy and intubation.

Detailed Description

Hemodynamic responses to laryngoscopy and intubation are a significant concern for the anesthesiologist. Laryngoscopy, tracheal intubation, surgical stimulation, and extubation unleash remarkable sympathetic activity and are associated with transient but significant hemodynamic changes. These hemodynamic derangements can be lethal in patients with multiple comorbidities. The need to blunt these noxious responses effectively has led to using several techniques and pharmacological agents, local anesthetics, beta-adrenergic-blockers, calcium channel antagonists, and opioids with varied success. This study aims to evaluate the effect of nebulized and intravenous either dexmedetomidine or lidocaine for attenuating the hemodynamic responses to laryngoscopy and intubation.

Eligibility

Age

18 - 50 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•The American Society of Anesthesiologists (ASA) physical status I \& II. BMI: ((≤ 35 kg/m2)). The patients are to be scheduled to undergo elective surgery under general anesthesia.
•Mallampati grade I, II

Exclusion Criteria

•Uncooperative patient. History of allergy to study drugs. Hemodynamically unstable patient. Renal or hepatic dysfunction or hypertensive patients.

Locations (1)

Faculty of medicine, Zagazig University

Zagazig, Al-Sharkia, Egypt

Key Dates

Start Date

July 12, 2023

Primary Completion Date

November 5, 2023

Completion Date

January 3, 2024

Last Updated

February 28, 2024

Enrollment

100

ACTUAL participants

Conditions

Anesthesia Intubation Complication

Interventions

Dexmedetomidine nebulization

DRUG

Lidocaine nebulization

DRUG

Dexmedetomidine IV

DRUG

Lidocaine IV

DRUG

Magnesium Sulfate in Surgical Stress Attenuation Postoperative Sore Throat and Stress Response Induced Tracheal Intubation

NCT06091631

Anesthesia ComplicationAnesthesia Intubation Complication

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UNKNOWNNA

Safety and Efficacy of Cleverscope. A New Medical Device for Tracheal Intubation

NCT03902704

Anesthesia Intubation ComplicationDifficult Intubation

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 28, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Dexmedetomidine or Lidocaine for Lessening the Hemodynamic Responses to Laryngoscopy and Intubation

Inclusion Criteria

Exclusion Criteria

Magnesium Sulfate in Surgical Stress Attenuation Postoperative Sore Throat and Stress Response Induced Tracheal Intubation

Safety and Efficacy of Cleverscope. A New Medical Device for Tracheal Intubation

Modified Rapid Sequence Induction in Morbidly Obese Patients

Paratracheal Force Required for Occluding the Upper Esophagus

Nasotracheal Tube Stenting by Nelaton Catheter in Pediatric Dental Surgery

The Effect of Prophylactic Ketorolac on Sore Throat After Thyroid Surgery