Exploration of Allograft Humoral Rejection in Chronic Histiocytic Intervillositis

Inclusion Criteria

• •Mother and father ≥ 18 years old
• •For mothers in the CHI group :
• •* History of a normal pregnancy (full term, alive child) or IUGR/MFIU or miscarriage(s) or abortion followed by at least 1 obstetrical complication such as IUGR, MFIU, miscarriage
• •* Diagnosis of chronic histiocytic intervillitis made by placental anatomopathological examination with CD68+ marking
• •For the mothers of the antiphospholipid syndrom group
• •* History of miscarriage(s)
• •* Having an anti-phospholipid syndrome
• •For mothers in the normal pregnancy group:
• •* Third consecutive pregnancy of normal course, at term (≥ 36 weeks of amenorrhea) with eutrophic child
• •For the mother and father:
• •o Consent to participate in the study and for the participation in the study of at least one child and/or the use of existing samples (placenta / fetal DNA) from at least one previous pregnancy with CHI for the CHI group or at least one previous miscarriage for the APS group
• •For the father:
• •o Father of the last pregnancy and of the child(ren) participating in the study
• •Exlusion criteria :
• •For mothers in the normal pregnancy group:
• •o Suspected or confirmed intra-amniotic infection
• •For all the mothers:
• •* History of blood transfusion
• •* History of allogeneic organ transplantation
• •For the mother and the father:
• •* Person under legal protection (guardianship, curatorship)