Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Immunogenicity of LP-98 Injection in Healthy Subjects

Exclusion Criteria

• •1. Allergic to the IP or its excipients, or medicine of the same class , or having a history of severe allergies (including any food allergy or drug allergy);
• •2. With history or family history of psychiatric, or history of chronic or serious disorders of the central nervous system, cardiovascular, hepatic, nephrological, pulmanory, digestive, metabolic, hematological or skeletal system etc., or definitive history of myelosuppression, orany other significant history of disease that may affect the safety or PK parameters in the PI's judgment;
• •3. Having positive result for human immunodeficiency virus antibody (HIV-Ab), hepatitis B surface antigen (HBsAg), hepatitis C antibody (HCV-Ab), or Treponema pallidum antibody;
• •4. Having clinically significant abnormal results of vital signs or laboratory tests required by the protocol;
• •5. Having clinically significant abnormality of 12-lead ECG, or having a QTcF interval (using Fridericia's correction) \> 450 ms for males or \> 470 ms for females;
• •6. With serum creatine clearance rate (Ccr) \< 80 ml/min/1.73 m2 (based on Cockcroft-Gault formula);
• •7. Known or suspected history of drug abuse (i.e., morphine, methamphetamine, ketamine, dimethylenedioxymethamphetamine, tetrahydrocannabinol acid, cocaine etc.), or having positive result for drug abuse;
• •8. With history of heavy alcohol consumption within 1 year prior to screening (more than 21 units of alcohol per week, i.e., 360 ml of 5% beer, 45 ml of 40% hard liquor, 120 ml of 12% wine, or positive alcohol test;
• •9. Smoking more than 5 cigarettes per day within 3 months prior to screening, or inability to comply with the prohibition of smoking during the study;
• •10. Consuming amount \> 6 servings of coffee, tea, cola, energy-drink, or other caffeine-containing product per day. One serving ≈ 120 mg of caffeine. Or consumed any caffeine-containing product within 24 hours prior to the dosing of the IP;
• •11. Had received vaccination within 30 days prior to screening, or planning to receive vaccination during the study;
• •12. Had received any prescription and non-prescription drugs, herbal remedies, or dietary supplements within 14 days prior to the dosing of the IP;
• •13. Participated in any other clinical trial within 3 months prior to screening;
• •14. Had received surgical operation within 3 months prior to screening, or planning to receive surgical operation during the study;
• •15. Currently pregnant or lactating women；
• •16. Had blood donation or blood loss over 200 mL within 3 months prior to screening, or planning to donate blood during the study；
• •17. Cannot tolerate venipuncture blood collection and/or have a history of blood or needle sickness
• •18. Other conditions considered to be ineligible for study entry in the PI's judgment