Evaluating the Effects of an Exercise Intervention on the Gut Microbiota in Stage II-III Colorectal Cancer Survivors

Inclusion Criteria

• •18-70 years of age
• •Previous diagnosis of stage II-III CRC cancer
• •No known current, recurrent, or metastatic disease
• •No comorbid or physical limitations that would limit participation at the discretion of the treating provider
• •At least 60 days to 3 years from last cancer-directed treatment (including surgery, chemotherapy, and radiation. Elective surgery, including ileostomy reversal, is not counted in this timing but patients must be able to eat a normal diet, without post-operative dietary limitations)
• •Body mass index (BMI) 18.5-35 kg/m\^2
• •Able to understand and willing to sign written informed consent in English
• •Access to phone for study contacts
• •Access to a smart phone or tablet to connect to the Polar H10 Heart rate sensor during remote exercise sessions and attend virtual exercise sessions
• •Be willing and able to attend up to 24 sessions in-person at the Fred Hutch Exercise Research Center Shared Resource or virtually via phone, Zoom, or Microsoft Teams, based on participant preference
• •Access to internet (internet access may be provided on a case-by-case basis to participants where access to internet would otherwise be the only barrier to participation)
• •Willingness to participate in all study activities
• •Completion of all run-in activities
• •Participants must have an Eastern Cooperative Oncology Group (ECOG) Scale of Performance Status score of 0 or 1 for performance status
• •Women must not be pregnant, breastfeeding, or planning to become pregnant