Parecoxib in Total Knee Arthroplasty

Exclusion Criteria

• •Adults who are not capable of giving their own consent
• •Pre-existing neuropathy (assessed in the history and physical examination)
• •Coagulation disturbance (assessed on history and physical examination, if clinically necessary, by blood test, i.e. platelets ≤ 100,000, international normalized ratio ≥ 1.4 or prothrombin time ≥ 50)
• •Renal failure (assessed by history and physical examination, if considered clinically necessary, by blood test, i.e. creatinine ≥ 1.04 mg/dl)
• •Hepatic impairment (assessed by history and physical examination, if considered clinically necessary, by blood tests, i.e. transaminases (GGT ≥ 50 u/lt)
• •Allergy to local anesthetics, morphine, paracetamol, ketorolac or parecoxib
• •Pregnancy
• •Chronic pain syndromes that require the use of opioids at home
• •Known history of sulfa allergy
• •History of ischemic heart disease
• •History of chronic gastritis or peptic ulcer