Evaluation of the Change in PSMA Expression in Prostate Cancer in Response to Hormonal Therapy

PRIMARY OBJECTIVE: I. To determine the early effects (at day 8) of hormonal therapy on PSMA modulation in patients with castration sensitive prostate cancer (CSPC) and castration resistant prostate cancer (CRPC) SECONDARY OBJECTIVES: I. To evaluate the effects of hormonal therapy on PSMA modulation at day 28 post-therapy in patients with CSPC and CRPC II. To evaluate whether the change in PSMA modulation after hormonal therapy initiation changes the tumor staging on PSMA PET as defined by the PROMISE V2 criteria. EXPLORATORY OBJECTIVES: I. To assess whether the initial change in PSMA modulation in response to hormonal therapy holds prognostic implications II. To assess for potential correlation between the early change in PSMA modulation and tumor characteristics such as Gleason score, and site of disease. III. To assess whether the baseline level of PSMA uptake holds prognostic implications in response to hormonal therapy OUTLINE: Patients will be divided (non-randomized) into 2 groups (CRPC or CSPC) and receive PSMA PET prior to start of therapy (standard of care), then again 8 days and 28 days after initiation of hormonal therapy. Participants will be followed for up to 5 years.