Production of Gut Microbiota-Derived Metabolites in Response to Different Fatty Acid Profiles

The gut microbiota interacts with the host's enteric and systemic functions through the production of gut microbiota-derived metabolites. A subset of these metabolites, the endocannabinoids (eCB) and their congeners are derived from fatty acids and play a crucial role in metabolic health. The research project aims to study gut microbiota-derived metabolites, including the eCB and their congeners, in response to a 2-day diet rich in polyunsaturated fatty acids or rich in saturated fatty acids in individuals with or without abdominal obesity and type 2 diabetes. The investigators hope to better understand the kinetic production of circulating endocannabinoidome mediators derived from fatty acids in the diet.